首页 | 本学科首页   官方微博 | 高级检索  
   检索      


Lactocepin secreted by Lactobacillus exerts anti-inflammatory effects by selectively degrading proinflammatory chemokines
Authors:von Schillde Marie-Anne  Hörmannsperger Gabriele  Weiher Monika  Alpert Carl-Alfred  Hahne Hannes  Bäuerl Christine  van Huynegem Karolien  Steidler Lothar  Hrncir Tomas  Pérez-Martínez Gaspar  Kuster Bernhard  Haller Dirk
Institution:1. Chair for Biofunctionality, ZIEL Research Center for Nutrition and Food Science, CDD Center for Diet and Disease, Technische Universität München, Gregor-Mendel-Straße 2, 85350 Freising-Weihenstephan, Germany;2. Department of Gastrointestinal Microbiology, German Institute of Human Nutrition Potsdam-Rehbrücke, Arthur-Scheunert-Allee 114–116, 14558 Bergholz-Rehbrücke, Germany;3. Chair of Proteomics and Bioanalytics, Technische Universität München, Emil-Erlenmeyer-Forum 5, 85354 Freising-Weihenstephan, Germany;4. Laboratorio de Bacterias Lácticas y Probióticos, Departamento de Biotecnología, Instituto de Agroquímica y Tecnología de Alimentos, 46100 Burjassot, Valencia, Spain;5. ActoGeniX NV Technologiepark 4, 9052 Zwijnaarde, Belgium;6. Department of Immunology and Gnotobiology, Institute of Microbiology, Academy of Sciences of the Czech Republic, 549 22 Novy Hradek, Czech Republic;7. Center for Integrated Protein Science Munich, Munich, Germany
Abstract:
><ol class=
  • Download : Download high-res image (211KB)
  • Download : Download full-size image
  • Highlights? PrtP-encoded lactocepin degrades proinflammatory chemokines, notably IP-10 ? Lactocepin reduces lymphocyte infiltration in an ileitis model ? Lactocepin lowers IP-10 levels and cecal inflammation in a colitis model ? Lactocepin-based therapy may be a treatment option for chemokine-mediated diseases
    Keywords:
    本文献已被 ScienceDirect PubMed 等数据库收录!
    设为首页 | 免责声明 | 关于勤云 | 加入收藏

    Copyright©北京勤云科技发展有限公司  京ICP备09084417号