脂联素基因单核苷酸多态性T45G与湖北汉族人2型糖尿病的遗传关联研究

采用病例.家系对照和随机病例.对照两种设计,分析了603例样本脂联素基因(Adiponectin,APMl)单核苷酸多态性(SNP)rs13061862(T45G)与湖北汉族人群2型糖尿病的相关性.在所有样本中,2型糖尿病病人的G等位基因及GG基因型频率显著高于正常人(G:42.0%比21.7%,P<0.001;GG:13.6%比4.5%,P=0.032);在180个病例.家系对照中,2型糖尿病患者的GG基因型频率显著高于对照组(GG:17.8%比5.6%,P=0.011);在423个随机病例.对照中,2型糖尿病患者GG基因型频率也显著高于对照组(GG:12.2%比3.9%,P=0.025);单因素Logistic回归分析显示,GG基因型是2型糖尿病的危险因子(OR=3.58,95%C/=1.70-7.54).这些结果表明,脂联素基因SNPT45G多态性与湖北汉族人群2型糖尿病的发生发展相关,GG基因型是中国湖北汉族人2型糖尿病的遗传危险因素.

Association studies of the APM1 SNP T45G with type 2 diabetes in Han population of Hubei Province

To investigate the association between the APM1 SNP rs 13061862 and type 2 diabetes mellitus (T2DM), a total of 603 Han subjects from Hubei Province were genotyped for the APM1 SNP T45G. Both family-based case- control and unrelated case-control designs were used. The frequencies of the G allele and GG genotype for T2DM patients were significantly higher than those for controls (G: 42.0% vs. 21.7%, P<0.001; GG: 13.6% vs. 4.5%, P= 0.032) in all subjects. The GG genotype was associated with higher risk of T2DM in family-based case-control groups (GG: 17.8% vs. 5.6%, P = 0.011), while the G allele and GG genotype for T2DM patients were significantly higher than those for controls in the unrelated case-control groups (GG: 12.2% vs. 3.9%, P = 0.025). Logistic regression analysis suggested that GG genotype was the genetic risk factors for T2DM (OR = 3.58, 95% CI = 1.70-7.54). In conclusion, the APM1 SNP T45G is associated with T2DM risk, and the GG genotype may be a genetic risk factor of T2DM in Han population of Hubei Province.