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Activation of paternally derived regulatory mechanism in early mouse embryo
Authors:D Sz?ll?si  Y Yotsuyanagi
Affiliation:1. School of Information Science and Technology, ShanghaiTech University, Shanghai, 201210, China;2. College of Medicine and Biological Information Engineering, Northeastern University, Shenyang, Liaoning 110169, China;3. Department of Biomedical Engineering, King''s College London, London SE1 7EH, United Kingdom;4. World-Class Research Center, “Digital Biodesign and Personalized Healthcare”, Sechenov University, Moscow, Russia;5. Blizard Institute, Barts & The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom;6. The First Hospital of China Medical University, Shenyang, Liaoning 110122, China;7. Neusoft Research of Intelligent Healthcare Technology, Co. Ltd., Shenyang, Liaoning 110169, China;8. Department of Electrical and Computer Engineering, Stevens Institute of Technology, Hoboken, NJ, United States of America;1. Hanoï Medical University Hospital, Dong Da, Hanoi, Viet Nam;2. Université Grenoble Alpes, Laboratoire d''Ecologie Alpine, Grenoble 38041, France; CNRS, UMR 5553, Grenoble, 38041, France;3. LabTAU, INSERM, U1032, 69000, Lyon, France;4. Hospices Civils de Lyon, Hôpital Edouard Herriot, Department of Vascular and Urinary Imaging, 69000, Lyon, France;5. Université de Lyon, Lyon 69003, France; Université Lyon 1, Lyon France; Faculté de Médecine, Lyon Est, 69003, Lyon, France
Abstract:A stage-specific occurrence of retrovirus-like elements (intracisternal particles) is regularly observed within the endoplasmic reticulum of early mouse embryos. A quantitative electron microscopic study was carried out on hybrid embryos issued from the matings between high- and low-producer mouse strains of intracisternal particles. The low-producer character behaved as dominant in all these crosses, and this enabled us to demonstrate the activation of paternally introduced regulatory mechanism in two-cell embryos and morulae. There was no sign of maternal effect in the results of reciprocal crosses.
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