Tuning exocytosis for speed: fast and slow modes |
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Authors: | Martin Thomas F J |
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Affiliation: | Department of Biochemistry, University of Wisconsin, 433 Babcock Drive, Madison, WI 53706, USA. tfmartin@facstaff.wisc.edu |
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Abstract: | Exocytic fusion reactions triggered by Ca(2+) are widespread in neural, endocrine, exocrine, hemapoetic and perhaps all cell types. These processes exhibit tremendous variation in latencies to fusion following a Ca(2+) rise and in rates of fusion. We review reported differences for synaptic vesicle (SV) and dense-core vesicle (DCV) exocytosis and attempt to identify key features in the molecular mechanisms of docking, priming and fusion of SVs and DCVs that may account for differences in speed. |
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