Prolonged activation of S6K1 does not suppress IRS or PI-3 kinase signaling during muscle cell differentiation |
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| Authors: | D Lee Hamilton Andrew Philp Matthew G MacKenzie Keith Baar |
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| Institution: | (1) Division of Molecular Physiology, James Black Centre, University of Dundee, Dundee, UK |
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| Abstract: | Background Myogenesis in C2C12 cells requires the activation of the PI3K/mTOR signaling pathways. Since mTOR signaling can feedback through
S6K1 to inhibit the activation of PI3K, the aim of this work was to assess whether feedback from S6K1 played a role in myogenesis
and determine whether siRNA mediated knockdown of S6K1 would lead to an increased rate of myotube formation. |
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