The expression of oncogenes in human developing liver and hepatomas |
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| Authors: | X K Zhang D P Huang D K Chiu J F Chiu |
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| Institution: | 1. Department of Biochemistry, University of Vermont, College of Medicine, Burlington, Vermont 05405 USA;2. Shanghai Institute of Biochemistry, Chinese Academy of Science, 320 Yueyang Road, Shanghai, China;3. Shanghai Institute of Digestive Disease, 145 Shangdong Zhong Road, Shanghai, China;1. Department of Pathology, Yale University School of Medicine, New Haven, CT 06510, USA;2. Yale Cancer Center, Yale University School of Medicine, New Haven, CT 06510, USA;1. Department of Interdisciplinary Medicine, `Aldo Moro’ University of Bari, Italy;2. INBB, National Institute for Biostructures and Biosystems, Rome, Italy;3. National Cancer Center, IRCCS Istituto Tumori `Giovanni Paolo II’, Bari, Italy;3. Department of Biological Sciences, Hunter College of the City University of New York, New York, New York 10065;4. Biochemistry Program, Graduate Center of the City University of New York, New York, New York 10016;5. Biology Program, Graduate Center of the City University of New York, New York, New York 10016;6. Department of Pharmacology, Weill Cornell College of Medicine, New York, New York 10021;1. Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology, 2–4, Hibikino Wakamatsu-ku Kitakyushu-shi, Fukuoka 8080196, Japan;2. School of Food Science and Engineering, Yangzhou University, Yangzhou 225127, China;1. Mayo Clinic Department of Pathology and Laboratory Medicine, United States;2. Department of Oncology, Mayo Clinic, Rochester, MN, United States;3. Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, United States;4. Department of Health Sciences Research, Mayo Clinic, Rochester, MN, United States;5. Division of Clinical Trials and Biostatistics, Mayo Clinic, Rochester, MN, United States;6. Division of Gastroenterology and Hepatology, Stanford University, Stanford, CA, United States;7. Department of Surgery, Keimyung University School of Medicine, Keimyung University Dongsan Hospital, Daegu, Republic of Kore;1. Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, Chongqing, China;2. Institute for Viral Hepatitis, Chongqing Medical University, Chongqing, China;3. Department of Infectious Diseases, Second Affiliated Hospital, Chongqing Medical University, Chongqing, China |
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| Abstract: | Oncogene expression was examined in the human fetal liver and human hepatomas. Erb (B), erb (A+B), Ha-ras, myc, fos and fms oncogene expression elevated in certain stages of fetal liver development and in hepatoma as compared to the normal adult human liver. In contrast, rel, src, mos, sis, myb, Ki-ras and bas oncogenes showed no apparent change of their mRNA levels during fetal liver development and in hepatoma. Further study of erb B oncogene expression in human cirrhotic liver and hepatoma demonstrated a strong correlation between erb B expression and alteration of its gene structure. |
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