Inhibition of 2'-phosphodiesterase by cAMP-dependent protein kinase. Involvement of phosphorylation of protein inhibitor |
| |
| Authors: | A V Itkes O N Kartasheva C A Kafiani E S Severin |
| |
| Affiliation: | Institute of Molecular Biology, Academy of Sciences of the USSR, 117984 Moscow, USSR |
| |
| Abstract: | 2'-Phosphodiesterase from NIH 3T3 cells was purified about 530-fold. Treatment of the cell lysate with the cAMP-dependent protein kinase causing the 2'-phosphodiesterase inhibition did not result in phosphorylation of the enzyme itself. The kinase was found to phosphorylate a specific 18-kDa protein, the phosphorylated form of this protein being the inhibitor of 2'-phosphodiesterase. |
| |
| Keywords: | cAMP-dependent protein kinase 2'-Phosphodiesterase 2'-Phosphodiesterase protein inhibitor |
| 本文献已被 ScienceDirect 等数据库收录！ |
