Immunoregulation through IL-10 gene expression and the fate of cytotoxic T lymphocyte-mediated tumor immunotherapy |
| |
Authors: | Nitya G. Chakraborty |
| |
Affiliation: | Department of Medicine, University of Connecticut School of Medicine, Farmington, CT 006030-1628, USA |
| |
Abstract: | Gene analysis of tumor associated antigens revealed that tumor antigens are all normal gene product. Inducing tumor reactive cytotoxic T lymphocytes (CT) in the patients is same as inducing autoimmunity in the patients. Immunosuppressive cytokine interleukin-10 (IL-10) plays an important role in maintaining homeostasis or tolerance. To break the tumor tolerance, blocking and IL-10 secretion or intervention in the pathways of IL-10 gene activation is indeed important. |
| |
Keywords: | Tumor antigens Cytotoxic T Lymphocyte (CTL) Regulatory T cells (Tregs) Interleukin-10 (IL-10) |
|
|