Cell cycle: how, when and why cells get rid of cyclin A. |
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Authors: | T Tin Su |
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Institution: | MCD Biology, University of Colorado, Boulder, Colorado 80309-0347, USA. tin.su@colorado.edu |
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Abstract: | Sequences outside the 'destruction box' direct the degradation of cyclin A to completion before the metaphase-anaphase transition; cyclin A that escapes timely degradation can block the metaphase-anaphase transition, impede anaphase and telophase, and impair a cell's ability to arrest in G1 of the next cell cycle. |
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