On origin of genetic code and tRNA before translation |
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| Authors: | Andrei S Rodin Eörs Szathmáry Sergei N Rodin |
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| Institution: | 1.Human Genetics Center, School of Public Health,University of Texas,Houston,USA;2.Collegium Budapest (Institute for Advanced Study),Budapest,Hungary;3.Parmenides Center for the Study of Thinking,Munich/Pullach,Germany;4.Institute of Biology,E?tv?s University,Budapest,Hungary;5.Department of Molecular and Cellular Biology,Beckman Research Institute of the City of Hope,Duarte,USA |
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| Abstract: | Background Synthesis of proteins is based on the genetic code - a nearly universal assignment of codons to amino acids (aas). A major
challenge to the understanding of the origins of this assignment is the archetypal "key-lock vs. frozen accident" dilemma.
Here we re-examine this dilemma in light of 1) the fundamental veto on "foresight evolution", 2) modular structures of tRNAs
and aminoacyl-tRNA synthetases, and 3) the updated library of aa-binding sites in RNA aptamers successfully selected in vitro for eight amino acids. |
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