A general framework for modeling growth and division of mammalian cells |
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Authors: | John H Gauthier Phillip I Pohl |
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Institution: | (1) Sandia National Laboratories, P.O. Box 5800, 87185-1188 Albuquerque, New Mexico, USA |
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Abstract: | Background Modeling the cell-division cycle has been practiced for many years. As time has progressed, this work has gone from understanding
the basic principles to addressing distinct biological problems, e.g., the nature of the restriction point, how checkpoints
operate, the nonlinear dynamics of the cell cycle, the effect of localization, etc. Most models consist of coupled ordinary
differential equations developed by the researchers, restricted to deal with the interactions of a limited number of molecules.
In the future, cell-cycle modeling--and indeed all modeling of complex biologic processes--will increase in scope and detail. |
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