Effect of chronic craving for ethanol on accumulation of calcium ions in intracellular structures of rat myometrium |
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Authors: | Borisova L A |
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Institution: | Palladin Institute of Biochemistry, NAS of Ukraine, Kyiv. LBorisova@biochem.kiev.ua |
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Abstract: | In the experiments on the impregnant estrogenized rats the effect of chronic ethanol intake on Ca(2+)-accumulative mitochondrial systems and endoplasmatic systems of myometrium was estimated. It was defined that in chronic alcohol consumption the transport activity of mitochondria Ca(2+)-accumulative systems didn't prevail over endoplasmatic reticulum Ca(2+)-accumulative activity. Therewith mitochondria and endoplasmatic Ca(2+)-transport system was essentially disturbed. In the tested conditions Mg2+, ATP-dependent sensitivity of calcium pump to oxytocin inhibiting action was shown to disappear. |
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