Intralymphatic administration of BCG in melanoma patients |
| |
Authors: | Natale Cascinelli Gian Paolo Balzarini Vincenzo Fontana Sergio Orefice Umberto Veronesi |
| |
Affiliation: | (1) WHO Collaborating Centres for the Evaluation of Methods of Diagnosis and Treatment of Melanoma: Istituto Nazionale per lo Studio e la Cura dei Tumori, Milano, Italy;(2) 14-16, avenue Paul-Vaillant-Couturier |
| |
Abstract: | Summary From November 1973 to December 1974, 20 patients with advanced malignant melanoma were treated with BCG given by intralymphatic route at the Cancer Institute of Milan. The lyophilized Pasteur BCG was used. Patients were treated with a single dose ranging from 0.2–80 mg. Patients' performance status was never severely impaired.The most frequent side effects were fever, lymphangitis, and lymph node enlargement.Variations were observed in white cell count, ERS and immunoglobulins; in no case did we find evidence of liver toxicity or tumor growth enhancement. It is concluded that the intralymphatic route is a safe way of administrating BCG. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|