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Dioxin interferes in chromosomal positioning through the aryl hydrocarbon receptor |
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| Authors: | Oikawa Kosuke Yoshida Keiichi Takanashi Masakatsu Tanabe Hideyuki Kiyuna Tomoharu Ogura Maki Saito Akira Umezawa Akihiro Kuroda Masahiko |
| Institution: | a Department of Pathology, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo 160-8402, Japan b Department of Cell Therapy, Tokyo Medical University, Tokyo 160-8402, Japan c Department of Biosystems Science, School of Advanced Sciences, The Graduate University for Advanced Studies, Kanagawa 240-0193, Japan d Biomedical Imaging and Informatics Group, Innovative Solutions Promotion Division, NEC Corporation, Tokyo 105-0014, Japan e Business Innovation Center, Central Research Laboratories, NEC Corporation, Tokyo 105-0014, Japan f National Research Institute for Child Health and Development, Tokyo 157-8535, Japan |
| Abstract: | Each chromosome occupies its own-specific space called a ‘territory’ within the interphase nucleus, and the arrangement of chromosome territories (CTs) is important in epigenetic mechanisms. The molecular mechanism to determine the positioning of CTs, however, remains unknown. On the other hand, dioxin is known to be the typical environmental pollutant that affects a wide variety of biological events in many species. Here, we show that dioxin enlarges the minimum distance between chromosome 12 and chromosome 16 territories in human preadipocyte cells, and the alteration of chromosome positioning is canceled by an aryl hydrocarbon receptor (AhR) antagonist α-naphthoflavone. Thus, AhR may be a key molecule to regulate chromosome positioning. Our results suggest a novel effect of dioxin toxicity, and demonstrate a clue to reveal the novel molecular mechanism for the arrangement of CTs. |
| Keywords: | Dioxin Aryl hydrocarbon receptor α-naphthoflavone Chromosome territory |
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