VEGF receptor protein-tyrosine kinases: structure and regulation |
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Authors: | Roskoski Robert |
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Affiliation: | Blue Ridge Institute for Medical Research, 3754 Brevard Road, Suite 116A, Box 19, Horse Shoe, NC 28742, USA |
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Abstract: | The human VEGF family consists of VEGF (VEGF-A), VEGF-B, VEGF-C, VEGF-D, and placental growth factor (PlGF). The VEGF family of receptors consists of three protein-tyrosine kinases (VEGFR1, VEGFR2, and VEGFR3) and two non-protein kinase co-receptors (neuropilin-1 and neuropilin-2). These components participate in new blood vessel formation from angioblasts (vasculogenesis) and new blood vessel formation from pre-existing vasculature (angiogenesis). Interaction between VEGFR1 and VEGFR2 or VEGFR2 and VEGFR3 alters receptor tyrosine phosphorylation. |
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Keywords: | CSF, colony stimulating factor PAE, porcine aortic endothelial PlGF, placental growth factor VEGFR, vascular endothelial growth factor receptor |
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