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Constitutive hypophosphorylation of extracellular signal-regulated kinases-1/2 and down-regulation of c-Jun in human gastric adenocarcinoma |
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| Authors: | Wu William Ka Kei Sung Joseph Joe Yiu Yu Le Li Zhi Jie Chu Kent Man Cho Chi Hin |
| Affiliation: | a Department of Pharmacology, Basic Medical Sciences Building, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China b Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Hong Kong, China c Institute of Digestive Diseases, The Chinese University of Hong Kong, Hong Kong, China d Department of Surgery, Queen Mary Hospital, Hong Kong, China |
| Abstract: | Hyperphosphorylation of extracellular signal-regulated protein kinases-1/2 (ERK1/2) is known to promote cancer cell proliferation. We therefore investigated the constitutive phosphorylation levels of ERK1/2 and the expression of its downstream targets c-Fos, c-Jun, and cyclooxygenase-2 (COX-2) in biopsied human gastric cancer tissues. Results showed that ERK1/2 phosphorylation and c-Jun expression were significantly lowered in gastric cancer compared with the non-cancer adjacent tissues. The expression of c-Fos, however, was not altered while COX-2 was significantly up-regulated. To conclude, we demonstrate that hypophosphorylation of ERK1/2 may occur in gastric cancer. Such discovery may have implication in the application of pathway-directed therapy for this malignant disease. |
| Keywords: | Extracellular signal-regulated protein kinases c-Fos c-Jun Cyclooxygenase Gastric cancer |
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