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Salt consumption-dependent association of the GNB3 gene polymorphism with type 2 DM |
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| Authors: | Daimon Makoto Sato Hidenori Sasaki Satoshi Toriyama Sayumi Emi Mitsuru Muramatsu Masaaki Hunt Steven C Hopkins Paul N Karasawa Shigeru Wada Kiriko Jimbu Yumi Kameda Wataru Susa Shinji Oizumi Toshihide Fukao Akira Kubota Isao Kawata Sumio Kato Takeo |
| Institution: | a Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology (DNHMED), Yamagata University School of Medicine, 2-2-2 Iida-Nishi, Yamagata 990 9585, Japan b 21st Century Center of Excellence Program Study Group, Yamagata University School of Medicine, Yamagata, Japan c HuBit Genomix Research Institute, Tokyo, Japan d Department of Social and Preventive Epidemiology, School of Public Health, The University of Tokyo, Tokyo, Japan e Department of Molecular Epidemiology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan f Cardiovascular Genetics Division, Department of Internal Medicine, University of Utah School of Medicine, UT, USA |
| Abstract: | The associations of the C825T polymorphism (rs5443) of the G-protein β3 subunit (GNB3) gene and eight adjacent single nucleotide polymorphisms (SNPs) with diabetes were examined using a Japanese population (n (M/W): 2956 (1335/1621); age: 63.0 ± 10.2 years). Fasting plasma glucose (FPG) levels were significantly associated with the C825T polymorphism and two flanking SNPs (rs2301339 and rs5446) (p = 0.002, 0.001, and 0.008, respectively). A case-control association study of the C825T polymorphism with diabetes using multiple logistic regression analysis showed a significant association of the genotypes TT + TC with an odds ratio of 0.62 (p = 0.008) independent of age, gender, and BMI. The effects of salt consumption on the association were then examined (n = 1635). The FPG levels were significantly associated with the C825T polymorphism only in subjects with low salt consumption (<12.44 g/day) (p = 0.002). A case-control association study also showed a significant association with diabetes only in subjects with low salt consumption (p = 0.006). |
| Keywords: | GNB3 G-protein β3 subunit DM diabetes |
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