Amelioration of delayed-type hypersensitivity responses by IL-27 administration |
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Authors: | Miyazaki Yoshiyuki Shimanoe Yohei Wang Seng Yoshida Hiroki |
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Affiliation: | Department of Biomolecular Sciences, Division of Molecular and Cellular Immunoscience, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga 849-8501, Japan |
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Abstract: | Interleukin (IL-) 27 is a member of the IL-12 cytokine family. Although recent analyses of WSX-1 (IL-27 receptor α chain)-deficient mice as well as in vitro studies using recombinant IL-27 revealed the immunosuppressive function of IL-27, in vivo role and therapeutic potential of IL-27 remain poorly elucidated. Here we investigated the effect of IL-27 administration on delayed-type hypersensitivity (DTH). While WSX-1-deficient mice showed higher DTH responses as shown by the degree of footpad swelling, administration of IL-27 significantly ameliorated the footpad swelling. Since the activation status of the draining lymph node cells were not affected by IL-27 deficiency, it was suggested that IL-27 affected the effector phase of the response. These results collectively indicate that IL-27 has a suppressive effect on activated T cells in the experimental model and also has a therapeutic potential for some diseases caused by immune disorder. |
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Keywords: | Cytokine Cytokine receptor Type IV allergy Inflammation T lymphocytes Type II interferon Knockout mice IL-27 IL-10 Delayed-type hypersensitivity Immune suppression |
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