| 眼镜蛇毒对成年大鼠齿状回Nestin表达的影响 |
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| 引用本文： | 吴锋,刘嵩,熊克仁,刘敏.眼镜蛇毒对成年大鼠齿状回Nestin表达的影响[J].蛇志,2012,24(2):96-98. |
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| 作者姓名： | 吴锋 刘嵩 熊克仁 刘敏 |
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| 作者单位： | 皖南医学院解剖学教研室,安徽芜湖,241002 |
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| 基金项目： | 皖南医学院中青年科研基金(项目编号:WK200929) |
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| 摘 要： | 目的探讨眼镜蛇毒对成年大鼠齿状回巢蛋白（Nestin）免疫反应阳性表达的影响。方法将24只成年SD大鼠随机分为正常对照组、生理盐水组、眼镜蛇毒组,每组8只。采用SABC免疫组织化学染色法观察齿状回Nestin的表达。结果与正常对照组、生理盐水组相比较,眼镜蛇毒组齿状回Nestin免疫反应阳性表达明显增强（P〈0.01）。结论眼镜蛇毒对成年大鼠齿状回Nestin的表达有上调作用,可能与促进内源性神经干细胞增殖有关。
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| 关 键 词： | 眼镜蛇毒 齿状回 巢蛋白 大鼠 |
Effect of Naja naja atra venom on expression of Nestin in dentate gyrus of adult rats |
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| WU Feng
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LIU Song
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XIONG Ke-ren
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LIU Ming.Effect of Naja naja atra venom on expression of Nestin in dentate gyrus of adult rats[J].Journal of Snake,2012,24(2):96-98. |
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| Authors: | WU Feng LIU Song XIONG Ke-ren LIU Ming |
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| Institution: | g(Department of Anatomy,Wannan Medical College,Wuhu,Anhui,241002,China) |
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| Abstract: | Objective To explore the effects of Naja naja atra venom on the expression of Nestin in the hippocampal dentate gyrus of adult rats.Methods Twenty-four Sprague-Dawley adult rats were randomized into normal control group,normal saline group and Naja naja atra venom group.Immunohistochemistry was used to observe the different expression of Nestin in the dentate gyrus.Results Compared with the normal control group and normal saline group,the expression of Nestin in the hippocampal dentate gyrus in the Naja naja atra venom group was increase significantly(P<0.01).Conclusion Naja naja atra venom could upregulate the expression of Nestin and possible concerned with the accelerate endogenous neural stem cells in the hippocampal dentate gyrus of adult rats. |
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| Keywords: | Naja naja atra venom Dentate gyrus Nestin Rat |
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