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C-terminus of heat shock protein 60 can activate macrophages by lectin-like oxidized low-density lipoprotein receptor 1 |
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| Authors: | Baonian Liu Shaoling Li Bingqiu Xiu Yaqi Zhang Yuxiang zhou Qinrui Yang Wanjun Qi Weicheng Wu Lan Wang Jianxin Gu Jianhui Xie | |
| Affiliation: | 1. Department of Forensic Medicine, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China;2. Department of Pathology, Fudan University Shanghai Cancer Centre, Shanghai, 200032, China;3. Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China;4. Key Laboratory of Glycoconjugate Research, Ministry of Health, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China | |
| Abstract: | Immune responses against antigens generally require an efficient activation of antigen-presenting cells (APCs). Currently, the targeting of vaccine antigens to APCs has emerged as a promising strategy for boosting vaccine immunogenicity. Here, we reported that the C-terminus of heat shock protein 60 (HSP60 | |
| Keywords: | HSP60-C OVA LOX-1 APCs APCs antigen-presenting cells DC dendritic cell Hsp heat shock protein Hsp60-C LOX-1 lectin-like oxidized low-density lipoprotein receptor-1 FACS fluorescence-activated cell sorting | |
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