Regulation of DGK‐θ |
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| Authors: | Becky Tu‐Sekine Daniel M. Raben |
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| Affiliation: | Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, Maryland |
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| Abstract: | Diacylglycerol kinases are important regulators of lipid signaling and, consequently, important regulators of many diglyceride‐dependent and PA‐dependent proteins. Research over the last twenty years has clearly demonstrated that individual DGK isoforms can be connected with disparate cellular processes, indicating the presence of a sophisticated regulatory network for diglyceride and phosphatidic acid signaling through the regulation of individual DGK isoforms. This review presents the progress on the characterization of a primarily neuronal isoform DGK‐θ, and examines current data on the primary structure, regulation and potential cellular functions of this enzyme. J. Cell. Physiol. 220: 548–552, 2009. © 2009 Wiley‐Liss, Inc. |
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