Increase in enzyme activities of prostaglandin biosynthesis and catabolism by acute ureteral ligation in rat kidney |
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| Authors: | S Fukuda Y Hamasaki H H Tai |
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| Affiliation: | Division of Medicinal Chemistry and Pharmacognosy College of Pharmacy, University of Kentucky Lexington, Kentucky 40536-0053, USA |
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| Abstract: | Acute ureteral obstruction increased cyclooxygenase, thromboxane and prostacyclin synthases and NAD+-linked 15-hydroxyprostaglandin dehydrogenase activities in rat kidney. Significant increase in prostaglandin biosynthetic and catabolic activities may mediate some pathological consequences found in obstructive nephropathy. |
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| Keywords: | To whom correspondence should be addressed. |
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