The response of germ cells of the mouse to the induction of non-disjunction by X-rays |
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Authors: | RM Speed AC Chandley |
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Institution: | MCR Clinical and Population Cytogenesis Unit, Western General Hospital, Crewe Road, Edinburgh, Scotland EH4 2XU, Great Britain |
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Abstract: | The sensitivity of male and female pre-meiotic germ cells of the mouse to the induction of non-disjunction by low doses of X-rays, has been tested. No enhancement with 5 rad was observed over control of values in dictyate oocytes irradiated from young or aged females. In males, a 3-fold increase in overall chromosome abnormalities (aneuploids, polyploids and mosaics) was found following the treatment of germ cells sampled in the 7th week after irradiation (spermatogonia and early primary spermatocytes) with 100 rad. The increase in aneuploidy alone was not however significant at the 5% level of probability. Primary spermatocytes sampled in week 5 after irradiation were generally insensitive to the induction of chromosome abnormalities. |
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