beta-Catenin: a pivot between cell adhesion and Wnt signalling |
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Authors: | Bienz Mariann |
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Affiliation: | MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH UK. mb2@mrc-lmb.cam.ac.uk |
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Abstract: | Mutual adhesion of animal cells is intimately linked to Wnt signaling through a shared component: beta-catenin, or Armadillo in Drosophila. Recent work indicates how beta-catenin shifts from cell adhesion to Wnt signaling, a switch associated with epithelial-mesenchymal transitions and cancer. |
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