Multiple telophase arrest bypassed (tab) mutants alleviate the essential requirement for Cdc15 in exit from mitosis in S. cerevisiae |
| |
Authors: | Wenying Shou Raymond J Deshaies |
| |
Institution: | (1) Division of Biology, 156-29 Howard Hughes Medical Institute, California Institute of Technology, Pasadena, CA 91125, USA |
| |
Abstract: | Background The Mitotic Exit Network (MEN) proteins – including the protein kinase Cdc15 and the protein phosphatase Cdc14 – are essential for exit from mitosis in Saccharomyces cerevisiae. To identify downstream targets of the MEN, we sought telophase arrest bypassed (tab) mutations that bypassed the essential requirement for CDC15. Previous studies identified net1 tab2-1 and CDC14 TAB6-1 as mutations in the RENT complex subunits Net1 and Cdc14, respectively, and revealed that the MEN acts by promoting release of Cdc14 from its nucleolar Net1 anchor during anaphase. However, the remaining tab mutants were not characterized. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|