An efficient paradigm for genetic epidemiology cohort creation |
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Authors: | Ladouceur Martin Leslie William D Dastani Zari Goltzman David Richards J Brent |
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Institution: | Department of Human Genetics, McGill University, Jewish General Hospital, Montreal, Canada. |
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Abstract: | Development of novel methodologies to efficiently create large genetic epidemiology cohorts is needed. Here we describe a rapid, precise and cost-efficient method for collection of DNA from cases previously experiencing an osteoporotic fracture by identifying cases using and administrative health-care databases. Over the course of 14 months we collected DNA from 1,130 women experiencing an osteoporotic fracture, at a cost of $54 per sample. This cohort is among the larger DNA osteoporotic fracture collections in the world. The novel method described addresses a major unmet health care research need and is widely applicable to any disease that can be identified accurately through administrative data. |
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