Antimicrobial activities of polyether compounds of dinoflagellate origins |
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Authors: | Hiroshi Nagai Masayuki Satake Takeshi Yasumoto |
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Affiliation: | 1. Taiyo Central R&D Institute, Taiyo Fishery Co. LTD., 3-2-9, Tsukishima, Chuo-ku, Tokyo, Japan 2. Faculty of Agriculture, Tohoku University, 1-1 Tsutsumidori-Amamiyamachi, Sendai, 981, Japan
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Abstract: | Twelve polyether compounds originating from dinoflagellates were tested for growth-inhibiting activities againstAspergillus niger, Penicillium funiculosum, Candida rugosa, Escherichia coli, Bacillus megaterium andStaphylococcus aureus by a paper disc method. These polyethers represent six groups of different skeletons and originate from three species;Prorocentrum lima, Dinophysis fortii andGambierdiscus toxicus. Potent antifungal activities were observed with okadaic acid and its two congeners, desulfated yessotoxin, and ciguatoxin but not with okadaic acid esters, prorocentrolide, pectenotoxin-1, yessotoxin, maitotoxin, and desulphated maitotoxin. The antifungal activities and mouse lethalities of the polyethers were markedly affected by slight modification of their structures. Antibacterial potency of the tested compounds was not significant. |
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