Amino acid sequence of human protein Z, a vitamin K-dependent plasma glycoprotein |
| |
Authors: | A Ichinose H Takeya E Espling S Iwanaga W Kisiel E W Davie |
| |
Institution: | Department of Biochemistry, University of Washington, Seattle 98195. |
| |
Abstract: | Protein Z is a vitamin K-dependent glycoprotein isolated and characterized from human and bovine plasma. A cDNA coding for human protein Z has been obtained by the isolation of phage clones from a liver cDNA library and in vitro amplification of two other liver libraries. Protein Z is synthesized with a prepro-leader sequence of 40 amino acids. The mature protein is composed of 360 residues including a Gla domain of 13 carboxyglutamic acid residues, two epidermal growth factor domains, and a carboxyl terminal region which is highly homologous to the catalytic domain of serine proteases. Human protein Z, however, contains an Asp instead of Ser and a Lys instead of His in the catalytic triad of the active site. |
| |
Keywords: | |
|
|