Two percent of men with early-onset prostate cancer harbor germline mutations in the BRCA2 gene |
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| Authors: | Edwards Stephen M,Kote-Jarai Zsofia,Meitz Julia,Hamoudi Rifat,Hope Questa,Osin Peter,Jackson Rachel,Southgate Christine,Singh Rashmi,Falconer Alison,Dearnaley David P,Ardern-Jones Audrey,Murkin Annette,Dowe Anna,Kelly Jo,Williams Sue,Oram Richard,Stevens Margaret,Teare Dawn M,Ponder Bruce A J,Gayther Simon A,Easton Doug F,Eeles Rosalind A Cancer Research UK/Bristish Prostate Group UK Familial Prostate Cancer Study Collaborators British Association of Urological Surgeons Section of Oncology |
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| Affiliation: | Translational Cancer Genetics Team, Institute of Cancer Research, Sutton, Surrey, United Kingdom. |
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| Abstract: | Studies of families with breast cancer have indicated that male carriers of BRCA2 mutations are at increased risk of prostate cancer, particularly at an early age. To evaluate the contribution of BRCA2 mutations to early-onset prostate cancer, we screened the complete coding sequence of BRCA2 for germline mutations, in 263 men with diagnoses of prostate cancer who were
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