| 重组人肝细胞生成素的生物学性能 |
| |
| 作者姓名： | Zhang Y Yang XM Wang G He FC |
| |
| 作者单位： | 1. 北京放射医学研究所,北京100850
2. 第三军医大学大坪医院消化科,400042 |
| |
| 摘 要： | 利用ＭＴＳ及３ＨＴｄＲ掺入法,首次观察了重组人肝细胞生成素（ｒｅｃｏｍｂｉｎａｎｔｈｕｍａｎｈｅｐａｔｏｐｏｉｅｔｉｎ,ｒｈＨＰＯ）在体外对原代培养大鼠肝细胞及肝癌细胞增殖的正向调控作用。结果表明ｒｈＨＰＯ是一种重要的肝细胞增殖刺激因子,可望成为临床治疗肝病的新药物。同时也观察到ｒｈＨＰＯ可以在体外抑制肺癌细胞ＤＮＡ的合成,为探究其作用机理提供了有益的提示。
|
| 关 键 词： | 人肝细胞生成素 生物学性能 |
Biological activity of recombinant human hepatopoietin |
| |
| Zhang Y,Yang XM,Wang G,He FC.Biological activity of recombinant human hepatopoietin[J].Acta Physiologica Sinica,1999,51(3):347-350. |
| |
| Authors: | Zhang Y Yang X M Wang G He F C |
| |
| Institution: | Institute of Radiation Medicine, Beijing 100850. |
| |
| Abstract: | We examined the effects of rhHPO on the cell growth and DNA synthesis of both rat primarily cultured hepatocytes and hepatic carcinoma cell line in vitro by MTS and 3H-TdR in corporation methods. It was indicated that rhHPO is an important stimulating factor of regeneration, which may be developed as a potential drug for the treatment of severe hepatic diseases. We also found an inhibitory effect of rhHPO on the DNA synthesis of lung cancer cell lines GLC-82 in vitro, which might provide a valuable indicator for the study of its specificity and mechanisms. |
| |
| Keywords: | recombinant human hepatopoietin (rhHPO) biological activity |
| 本文献已被 CNKI 维普 万方数据 PubMed 等数据库收录！ |
