Interaction of covalently closed circular PM-2 DNA and hedamycin. |
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| Authors: | S Mong J E Strong S T Crooke |
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| Institution: | 1. Department of Pharmacology, Baylor College of Medicine, Houston, Texas 77025 USA;2. Bristol Laboratories, Syracuse, New York 13201 USA |
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| Abstract: | The interaction of hedamycin with covalently closed circular PM-2 DNA was examined. Hedamycin produced strand breakage detectable in alkaline sucrose gradients. Under neutral conditions hedamycin inhibited ethidium bromide binding and induced conformational changes in PM-2 DNA. |
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| Keywords: | Reprint requests to S M |
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