An integrated computational pipeline and database to support whole-genome sequence annotation |
| |
| Authors: | Mungall C J Misra S Berman B P Carlson J Frise E Harris N Marshall B Shu S Kaminker J S Prochnik S E Smith C D Smith E Tupy J L Wiel C Rubin G M Lewis S E |
| |
| Affiliation: | Howard Hughes Medical Institute, University of California, Berkeley, CA 94720, USA. cjm@fruitfly.org |
| |
| Abstract: | We describe here our experience in annotating the Drosophila melanogaster genome sequence, in the course of which we developed several new open-source software tools and a database schema to support large-scale genome annotation. We have developed these into an integrated and reusable software system for whole-genome annotation. The key contributions to overall annotation quality are the marshalling of high-quality sequences for alignments and the design of a system with an adaptable and expandable flexible architecture. |
| |
| Keywords: | |
| 本文献已被 PubMed SpringerLink 等数据库收录！ |
