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常见肠道菌群代谢产物作为疾病诊断的指针的研究进展
引用本文:韩睿盈,姜志深,高灿宇,任彪. 常见肠道菌群代谢产物作为疾病诊断的指针的研究进展[J]. 微生物学通报, 2021, 48(11): 4261-4274
作者姓名:韩睿盈  姜志深  高灿宇  任彪
作者单位:四川大学华西口腔医院 国家口腔疾病临床医学研究中心 口腔疾病国家重点实验室 四川 成都 610041;四川大学华西医院康复医学中心 康复医学四川省重点实验室 四川 成都 610041
基金项目:国家自然科学基金(81870778);四川省科技计划项目(2020YJ0227)
摘    要:人类肠道菌群能够产生多种代谢产物或与人体相互作用产生肠道菌群-宿主共代谢物,显著影响人体各大系统的生理功能。当人体健康状态以及肠道菌群发生变化时,肠道代谢物的种类和含量也会相应受到影响,因此肠道菌群代谢产物具有作为疾病诊断指针的巨大潜力。本文总结了常见的几类肠道微生物代谢产物,包括糖类、胆碱代谢物、脂质、氨基酸与肽类、维生素、胆汁酸、短链脂肪酸、酚、苯甲酰基和苯基衍生物等,及其在不同疾病状态下的作用机理,以期更好地理解肠道菌群、代谢产物和疾病之间的相关性,为疾病的预防、诊断和治疗提供新的靶点。

关 键 词:肠道菌群  代谢产物  疾病诊断  检测方法
收稿时间:2021-01-21

Research progress of intestinal flora metabolites as indicators for disease diagnosis
HAN Ruiying,JIANG Zhishen,GAO Canyu,REN Biao. Research progress of intestinal flora metabolites as indicators for disease diagnosis[J]. Microbiology China, 2021, 48(11): 4261-4274
Authors:HAN Ruiying  JIANG Zhishen  GAO Canyu  REN Biao
Affiliation:State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China;Rehabilitation Key Laboratory of Sichuan Province, Center of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China
Abstract:The human intestinal flora can produce a variety of metabolites, or interact with human body to produce intestinal flora-host co-metabolites, which can impact the physiological functions of the major body systems. When the health conditions and intestinal flora change, the types and content of the metabolites will be affected accordingly, which indicate that the intestinal flora metabolites can be potential indicators for disease diagnosis. This article summarizes several common types of intestinal microbial metabolites, including carbohydrates, choline metabolites, lipids, amino acids and peptides, vitamins, bile acids, short-chain fatty acids, phenols, and benzoyl and phenyl derivatives. Furthermore, we expound their mechanisms of action in different diseases to highlight the correlations between intestinal flora, metabolites, and diseases, and to indicate that intestinal metabolites can be served as the new targets for the prevention, diagnosis, and treatment of these diseases.
Keywords:intestinal flora  metabolite  disease diagnosis  detection technology
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