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In vitro potentiation of the activity of synthetic ovine corticotropin-releasing factor by arginine vasopressin |
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| Authors: | C M Turkelson C R Thomas A Arimura D Chang J K Chang M Shimizu |
| Institution: | 1. Laboratories for Molecular Neuroendocrinology and Diabetes, Tulane University Hebert Research Center Belle Chasse, LA 70037, USA;2. Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA;3. Department of Anatomy, Tulane University School of Medicine, New Orleans, LA 70112, USA;4. Veterans Administration Medical Center, New Orleans, LA 70146, USA;5. Peninsula Laboratories, San Carlos, CA 94070, USA |
| Abstract: | The ability of arginine vasopressin (AVP) to potentiate the actions of synthetic ovine corticotropin-releasing factor (CRF) was examined using anterior pituitary fragments. Marked potentiation of ACTH release was observed upon incubating the fragments with a combination of 2 nM AVP and 1 nM CRF. Potentiation of CRF-induced ACTH release was also observed when the fragments were incubated with a combination of 1 nM AVP and 0.5 nM CRF. These results suggest that AVP may play a role in the release of ACTH from the adenohypophysis. |
| Keywords: | Corticotropin-releasing factor Arginine vasopressin |
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