Effect of 5'-deoxy-5'-S-isobutyladenosine on hematopoietic stem cells

Unlike known cytostatics, 5'-deoxy-5'-S-isobutyladenosine (SIBA) does not inhibit proliferative activity of hemopoietic stem cells of intact bone marrow. On the contrary, it raises CFUs number of 15-28% in vitro and in vivo. SIBA inhibits by 40% the 3',5'-cAMP-induced increase in CFUs proliferation.