Mapping the diabetes polygene Idd3 on mouse Chromosome 3 by use of novel congenic strains |
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| Authors: | C J Lord S K Bohlander E A Hopes C T Montague N J Hill J -B Prins R J Renjilian L B Peterson L S Wicker J A Todd P Denny |
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| Institution: | (1) Nuffield Department of Surgery, The Wellcome Trust Centre for Human Genetics, University of Oxford, Windmill Road, Headington, OX3 7BN Oxford, UK;(2) Section of Haematology/Oncology, Department of Medicine, MC 2115, 5841 S. Maryland Ave., 60637-1470 Chicago, Illinois, USA;(3) Department of Cellular and Molecular Pharmacology, Merck Research Laboratories, 07065 Rahway, New Jersey, USA;(4) Department of Autoimmune Diseases Research, Merck Research Laboratories, 07065 Rahway, New Jersey, USA |
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| Abstract: | Development of novel congenic mouse strains has allowed us to better define the location of the diabetogenic locus, Idd3, on Chromosome (Chr) 3. Congenic strains were identified by use of published and newly developed microsatellite markers, their genomes fingerprinted by a rapid, fluorescence-based approach, and their susceptibility to type 1 diabetes evaluated. The maximum interval containing Idd3 is now approximately 4 cM. |
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