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Synthesis,crystal structure,antitumor activity and DNA-binding study on the Mn(II) complex of 2H-5-hydroxy-1,2,5-oxadiazo[3,4-f]1,10-phenanthroline |
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| Authors: | Xu Zhi Dong Liu He Xiao Su Long Yang Ming Bu Xian He |
| Institution: | a National Research Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100083, PR China b Department of Chemistry, Nankai University, Tianjin 300071, PR China |
| Abstract: | The complex Mn(L)(NO3)2(H2O)2] (1) (L=2H-5-hydroxy-1,2,5-oxadiazo3,4-f]1,10-phenanthroline) was synthesized and characterized by elemental analysis, IR and UV. The crystal and molecular structure of 1 was determined by single-crystal X-ray diffraction; crystal data: light yellow, monoclinic, space group P21/n, Z=4, a=7.432(2) Å, b=9.582(3) Å, c=23.445(7) Å, β=90.519(5)°. The Mn atom in 1 is hexa-coordinated in a distorted octahedral arrangement by two N atoms of the ligand L and four O atoms of two water molecules and two nitrate anions. Biological tests in vitro showed that 1 has significant antitumor activity against HL-60, KB, Hela and BGC-823 cells. The interaction of 1 with calf thymus DNA was investigated by absorption titration, thermal denaturation and viscosity measurements. The results suggest that 1 binds with DNA by intercalating via the ligand L. |
| Keywords: | Mn(II) complex 2H-5-Hydroxy-1 2 5-oxadiazo[3 4-f]1 10-phenanthroline Crystal structure Antitumor activity DNA-binding interaction |
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