Molecular analysis of ependymins from the cerebrospinal fluid of the orders clupeiformes and salmoniformes: no indication for the existence of an euteleost infradivision |
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Authors: | Angelika Müller-Schmid Bernhard Ganß Thomas Gorr Werner Hoffmann |
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Affiliation: | (1) Max-Planck-Institut für Psychiatrie, Abteilung Neurochemie, Am Klopferspitz 18A, D-82152 Martinsried, Germany;(2) Max-Planck-Institut für Biochemie, Am Klopferspitz 18A, D-82152 Martinsried, Germany |
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Abstract: | Summary Ependymins represent the predominant protein constituents in the cerebrospinal fluid of many teleost fish and they are synthesized in meningeal fibroblasts. Here, we present the ependymin sequences from the herring (Clupea harengus) and the pike (Esox lucius). A comparison of ependymin homologous sequences from three different orders of teleost fish (Salmoniformes, Cypriniformes, and Clupeiformes) revealed the highest similarity between Clupeiformes and Cypriniformes. This result is unexpected because it does not reflect current systematics, in which Clupeiformes belong to a separate infradivision (Clupeomorpha) than Salmoniformes and Cypriniformes (Euteleostei). Furthermore, in Salmoniformes the evolutionary rate of ependymins seems to be accelerated mainly on the protein level. However, considering these inconstant rates, neither neighbor joining trees nor DNA parsimony methods gave any indication that a separate euteleost infradivision exists. |
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Keywords: | Evolution Teleostei Clupea harengus Esox lucius Fish Polymerase chain reaction Calcium binding |
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