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Increased uptake sites for serotonin and dopamine with decreased S2 serotonin receptors in microencephalic rat brain |
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| Authors: | Masavuki Watanabe Masayuki Kinuya Gunji Mamiya Toshihiko Tatsunuma Michiko Nagayoshi Tenhoshimaru Matsutani Yasuzo Tsukada |
| Affiliation: | (1) Department of Psychiatry, National Defense Medical College, 3-2 Namiki, Tokorozawa, 359 Saitama, Japan;(2) Department of Biochemisty, National Defense Medical College, Saitama, Japan;(3) Department of Developmental Physiology, Institute for Comprehensive Medical Sciences, Fujita-Gakuen Health University School of Medicine, Aichi, Japan;(4) Department of Physiology, Kcio University School of Medicine, Tokio, Japan |
| Abstract: | Methylazoxymethanol (MAM)-induced cerebral hypoplasia resulted in a significant increase in densities of both serotonin uptake sites in frontal cortex and dopamine uptake sites in striatum, suggesting serotonergic and dopaminergic axon terminals were compressed in the smaller brain volumes. The density of S2 serotonin receptors in MAM-lesioned frontal cortex was decreased probably due to down-regulation, while densities of D1 and D2 dopamine receptors in striatum were identical between MAM-lesioned rats and control rats. |
| Keywords: | Methylazoxymethanol microencephaly serotonin dopamine uptake sites receptors |
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