Genetic nomenclature for chicken immunoglobulin allotypes: An extensive survey of inbred lines and antisera |
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Authors: | James M. Foppoli Lean Kuan Ch'ng Albert A. Benedict Juraj Ivanyi Josef Derka Edward K. Wakeland |
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Affiliation: | (1) Department of Microbiology, University of Hawaii, 96822 Honolulu, Hawaii;(2) Department of Experimental Immunobiology, Wellcome Research Laboratories, BR3 3BS Beckenham, Kent, England;(3) Department of Epizootiology and Microbiology, University of Veterinary Science, Brno, Czechoslovakia;(4) Department of Immunogenetics, Max Planck Institute for Biology, Tübingen, Federal Republic of Germany |
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Abstract: | Based on a survey of 36 inbred and 8 partially inbred chicken lines and outbred jungle fowl, and with 29 alloantisera generated in different laboratories, 13 7S Ig and 5 IgM allotypes were designated and a new system of nomenclature for chicken Ig polymorphisms was developed. The survey also revealed considerable genetic polymorphism in the structural gene(s) (G-1) responsible for the production of 7S Ig H chains. IgM H chains, encoded by theM-1 locus were less polymorphic. NineG-1 and fourM-1 gene alleles were delineated in highly inbred lines by the formation of unique combinations ofG-1 orM-1 specificities. Five additionalG-1 alleles were found in chicken lines and jungle fowl segregating for allotypes. Thirty-three percent of theG-1M-1 haplotypes theoretically expected, were detected in inbred lines. |
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