表皮生长因子及受体在甲状腺肿瘤中的表达

目的:研究表皮生长因子(Epidermal Growth Factor,EGF)及受体(Epidermal Growth Factor Receptor,EGFR)及在甲状腺肿瘤中的表达。方法:应用免疫组织化学法检测91例甲状腺病变组织中EGFR和EGF的表达情况。结果:结节性甲状腺肿、甲状腺腺瘤、分化型甲状腺癌标本中EGFR表达的阳性率分别为15%、25%、68.62%,EGF表达的阳性率分别为10%、15%、68.62%,其中EGFR、EGF在分化型甲状腺癌与其余两组间差异均有统计学意义(P<0.05)。EGFR和EGF在甲状腺乳头状癌中的表达与性别、年龄、肿瘤大小、淋巴结转移、临床分期等临床因素无明显相关。结论:EGF和EGFR的表达可作为鉴别甲状腺肿瘤良恶性的一个指标。

The Expression of Epidermal Growth Factor and Epidermal Growth Factor Receptor in Thyroid Neoplasm

Objective:To study the expression of epidermal growth factor (EGF)and epidermal growth factorreceptor (EGFR) in thyroid neoplasm.Methods:Immunohistochemical technique (SP method) was used to detect the expression of EGFR and EGF in 91 cases of thyroid neoplasm,and then the relationship between the expression and the major clinical pathological parameters was analyzed. Results:The positive rates of EGFR in nodular goiter,thyroid adenoma and differentiated thyroid cancer were 15%,25% and 68.62%. The positive rates of EGF in nodular goiter,thyroid adenoma and differentiated thyroid cancer were 10%,15% and 68.62%.The results showed that the expression of EGFR,EGF in thyroid cancer was significantly higher than that in benign thyroid tumor (P<0.05).The expression of EGFR and EGF in papillary thyroid cancer was not correlated with the gender and the age of the patients,the diameter of the tumor,the presence of lymph nodes metastasis and the clinical stage.Conclusion:The expression of EGFR and EGF may be served as a marker in identifying thyroid cancer and thyroid innocuous node,but not so useful in assessing clinical characteristics of papillary thyroid cancer.