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兰州市婴幼儿艰难梭菌带菌状况
引用本文:王成怀 邝欣. 兰州市婴幼儿艰难梭菌带菌状况[J]. 微生物学免疫学进展, 1994, 22(1): 2-5
作者姓名:王成怀 邝欣
作者单位:卫生部兰州生物制品研究所
摘    要:在兰州市随机采集的216名健康婴幼儿粪标本经分离并对其培养特性、菌落菌体形态特征、生化反应特性以及毒素原性等进行一系列检查,检出了37人的粪便含有艰难梭菌(104─108/g),检出总阳性率为17.1%,新生儿、婴儿及幼儿各年龄组的检出阳性率分别为13.5%(19/41)、33.3%(13/39)、13.9%(5/36)。37株分离菌中毒素原性阳性者仅有8株(21.6%),均分布于婴儿与幼儿两组。新生儿141人中27人的粪标本为胎粪,只有1人(3.7%)含艰难梭菌(2×106/g),但不产毒素。所有婴幼儿中有22人因各种原因曾用过抗菌药物,但仅有2人的粪便含艰难梭菌,而且均为非产毒株,表明艰难梭菌检出率与药物服用之间似无显著的相关性。

关 键 词:艰难梭菌,婴幼儿,带菌状况

Epidemiological Investigation on Clostridium difficile in Infants in Lanzhou
Wang Chenghuai et al. Epidemiological Investigation on Clostridium difficile in Infants in Lanzhou[J]. Progress In Microbiology and Immunology, 1994, 22(1): 2-5
Authors:Wang Chenghuai et al
Abstract:Fecal specimens from 216 infants aged one day to three months in Lanzhou were investigated for the presence of C. difficile and its toxin. Of these infants, 37 (17.1%) were found to be harboring C. difficile(about 104-108/g); however, none of them contain toxin in their stools.Of the.141 neonates aged less than 1 month, C. difficile was isolated from 19 (13.5%),whereas 13 (33.3%) of 19 infants aged between 1 and 12 months, were found to have C. difficile in their stools. Of the 36 infants aged between 1 and 3 years, 5 carried C. difficile in the specimens.Of the 37 isolates, only 8(21.6%) from the infants aged between 1 month and 3 years, were found to be toxigenic. Of the 27 meconiums taken from neonats, only one contained nontoxigenic C. difficile (2×106/g).Only two stool specimens from 22 infants who had used some antibiotics due to certain reasons, contained nontoxigenic C. difficile. Thus it appears that there is no Obvious relationship between the colonization of C. difficile and the medicines.
Keywords:Clostridium difficile   infants   carriers  
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