Biochemical genetics of Es-14 (formerly Es-Si) and a new esterase variation,Es-15, of the laboratory rat (Rattus norvegicus): Biochemistry,tissue expression,and linkage to Es-1 in linkage group V |
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| Authors: | Hans J. Hedrich Otto von Deimling Reinhart Kluge |
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| Affiliation: | (1) Zentralinstitut für Versuchstierzucht, Hermann Ehlers Allee 57, D-3000 Hannover 91, Bundesrepublik Deutschland;(2) Pathologisches Institut, Abteilung für Chemische Pathologie, Universität Freiburg, D-7800 Freiburg i. Br., Bundesrepublik Deutschland;(3) Abteilung Versuchstierkunde und Zentrallaboratorium für Versuchstiere, Medizinische Fakultät der RWTH Aachen, Bundesrepublik Deutschland |
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| Abstract: | The segregation of rat esterases controlled by loci residing in linkage group V (LGV) has been studied in two backcross series, (LEW/Han × BN/Han)F1 × LEW/Han and (LEW/Han × LE/Han)F1 × LEW/Han. Es-14 (formerly Es-Si) was shown to be closely linked to Es-1. A new esterase locus, Es-15, was described which codes for a liver isozyme. The distribution pattern of three alleles at the Es-15 locus is presented for 52 independent inbred strains. Close linkage of Es-15 to Es-14 and to Es-1 was established, proposing the following gene order: [Es-2, Es-10]—[ES-1, ES-14, ES-15]. The esterase loci on LGV are thus separated into two gene clusters, cluster 1 and cluster 2. These conclusions are supported by the strain distribution patterns of the two RI strain series, LXB and DXE.Otto von Deimling was supported by the Deutsche Forschungsgemeinschaft (De 315/2-1, communication No. 56). |
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| Keywords: | Rattus norvegicus electrophoresis carboxylesterases (EC 3.1.1.1) polymorphism strain distribution linkage group V esterase gene cluster 2 |
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