HTRA proteases: regulated proteolysis in protein quality control |
| |
Authors: | Clausen Tim Kaiser Markus Huber Robert Ehrmann Michael |
| |
Affiliation: | Research Institute of Molecular Pathology, Dr. Bohrgasse 7, A-1030 Vienna, Austria. tim.clausen@imp.ac.at |
| |
Abstract: | Controlled proteolysis underlies a vast diversity of protective and regulatory processes that are of key importance to cell fate. The unique molecular architecture of the widely conserved high temperature requirement A (HTRA) proteases has evolved to mediate critical aspects of ATP-independent protein quality control. The simple combination of a classic Ser protease domain and a carboxy-terminal peptide-binding domain produces cellular factors of remarkable structural and functional plasticity that allow cells to rapidly respond to the presence of misfolded or mislocalized polypeptides. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |