| Connexin 43在细胞死亡中的作用 |
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| 引用本文： | 宋东莉,刘晓宇,刘雯,左伋. Connexin 43在细胞死亡中的作用[J]. 生命科学, 2010, 0(3): 272-277 |
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| 作者姓名： | 宋东莉 刘晓宇 刘雯 左伋 |
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| 作者单位： | 复旦大学上海医学院细胞与遗传医学系; |
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| 摘 要： | 缝隙连接蛋白在细胞膜表面聚合形成半通道,部分两两结合构成缝隙连接通道,两者与胚胎发育、肿瘤发生及某些心脑血管疾病有关。Connexin 43(Cx43)在心肌细胞和神经细胞高表达,在多种缺血性心脑疾病及缺血再灌注损伤的病理过程中具有重要作用。近来有研究发现,Cx43也存在于线粒体和细胞核,分别参与心肌保护和细胞分化。该文以心肌细胞和神经细胞为主讨论近年来Cx43在细胞死亡中的作用的研究进展。
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| 关 键 词： | Connexin 43 缝隙连接 半通道 细胞死亡 凋亡 |
Effects of Connexin 43 on cell death |
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| SONG Dong-li,LIU Xiao-yu,LIU Wen,ZUO Ji. Effects of Connexin 43 on cell death[J]. Chinese Bulletin of Life Sciences, 2010, 0(3): 272-277 |
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| Authors: | SONG Dong-li LIU Xiao-yu LIU Wen ZUO Ji |
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| Affiliation: | SONG Dong-li,LIU Xiao-yu,LIU Wen,ZUO Ji(Department of Cellular , Genetic Medicine,Shanghai Medical College,Fudan University,Shanghai 200032,China) |
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| Abstract: | Gap junction proterin,connexins,which oligomerize to form hemichannels or gap junction channels that dock to different membrane surfaces,plays an essential role in embryonic development,tumorigenesis,and progression of kinds of myocardial and mental disease.Connexin 43(Cx43) is highly expressed in cardiomyocytes and neurocytes and involved in pathologic processes of ischemic conditions and ischemia-refusion.Recent studies show that Cx43 is located in mitochondria and nucleus. |
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| Keywords: | Connexin 43 gap junction hemichannel cell death apoptosis |
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