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Mechanisms that mediate stem cell self-renewal and differentiation
Authors:Zhang Haojian  Wang Zack Z
Affiliation:Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough, Maine 04074, USA.
Abstract:Stem cells have two common properties: the capacity for self-renewal and the potential to differentiate into one or more specialized cell types. In general, stem cells can be divided into two broad categories: adult (somatic) stem cells and embryonic stem cells. Recent evidence suggested that tumors may contain "cancer stem cells" with indefinite potential for self-renewal. In this review, we will focus on the molecular mechanisms regulating embryonic stem cell self-renewal and differentiation, and discuss how these mechanisms may be relevant in cancer cells.
Keywords:stem cells  embryonic stem cells  self‐renewal  pluripotency
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