Exploratory study of plasma total homocysteine and its relationship to short-term outcome in acute ischaemic stroke in Nigerians |
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| Authors: | Njideka U Okubadejo Olajumoke O Oladipo Adekunle A Adeyomoye Gbolahan O Awosanya Mustapha A Danesi |
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| Affiliation: | (1) Department of Medicine, College of Medicine, University of Lagos, Lagos, Nigeria;(2) Department of Chemical Pathology, College of Medicine, University of Lagos, Lagos, Nigeria;(3) Department of Radiation Biology, Radiotherapy and Radiodiagnosis, College of Medicine, University of Lagos, Lagos, Nigeria |
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| Abstract: | Background Hyperhomocysteinemia is a potentially modifiable risk factor for stroke, and may have a negative impact on the course of ischaemic stroke. The role of hyperhomocysteinemia as it relates to stroke in Africans is still uncertain. The objective of this study was to determine the prevalence and short-term impact of hyperhomocysteinemia in Nigerians with acute ischaemic stroke. We hypothesized that Hcy levels are significantly higher than in normal controls, worsen stroke severity, and increase short-term case fatality rates following acute ischaemic stroke. |
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