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The IGS Standard Operating Procedure for Automated Prokaryotic Annotation |
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| Authors: | Galens Kevin Orvis Joshua Daugherty Sean Creasy Heather H Angiuoli Sam White Owen Wortman Jennifer Mahurkar Anup Giglio Michelle Gwinn |
| Affiliation: | Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA. |
| Abstract: | The Institute for Genome Sciences (IGS) has developed a prokaryotic annotation pipeline that is used for coding gene/RNA prediction and functional annotation of Bacteria and Archaea. The fully automated pipeline accepts one or many genomic sequences as input and produces output in a variety of standard formats. Functional annotation is primarily based on similarity searches and motif finding combined with a hierarchical rule based annotation system. The output annotations can also be loaded into a relational database and accessed through visualization tools. |
| Keywords: | Institute for Genome Sciences functional annotation structural annotation microbial genomics prokaryotic genomics annotation pipeline pFunc Glimmer HMM BER Ergatis Manatee IGS Annotation Engine |
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