Surfactin from Bacillus subtilis displays anti-proliferative effect via apoptosis induction, cell cycle arrest and survival signaling suppression |
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Authors: | Kim Seo-Young Kim Joo Young Kim Seol-Hee Bae Hyun Jin Yi Hwaseon Yoon Sang Hong Koo Bon Sung Kwon Moosik Cho Jae Youl Lee Choong-Eun Hong Sungyoul |
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Affiliation: | Department of Genetic Engineering, Sungkyunkwan University, Suwon 440-746, Republic of Korea. |
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Abstract: | The effect of surfactin on the proliferation of LoVo cells, a human colon carcinoma cell line, was examined. Surfactin strongly blocked the proliferation of LoVo cells by inducing pro-apoptotic activity and arresting the cell cycle, according to several lines of evidence on DNA fragmentation, Annexin V staining, and altered levels of poly (ADP-ribose) polymerase, caspase-3, p21(WAF1/Cip1), p53, CDK2 and cyclin E. The anti-proliferative activity of surfactin was mediated by inhibiting extracellular-related protein kinase and phosphoinositide 3-kinase/Akt activation, as assessed by phosphorylation levels. Therefore, our data suggest that surfactin may have anti-cancer properties as a result of its ability to downregulate the cell cycle and suppress its survival. |
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Keywords: | CDKs, cyclin-dependent kinases ERK, extracellular-related protein kinase IKK, IκB kinase JNK, C-Jun N-terminal kinase MAPK, mitogen-activated protein kinase PARP, poly (ADP-ribose) polymerase PI3K, phosphoinositide 3-kinase |
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