Studies on an unstable phenotype induced by UV irradiation |
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Authors: | Claude-Michel Gaillardin Geneviève Sylvestre Henri Heslot |
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Affiliation: | 1. Laboratoire de Génétique, Institut National Agronomique Paris-Grignon, Paris
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Abstract: | Unstable clones excreting L-lysine into their growth medium are obtained at a very high frequency following UV irradiation in both haploid and diploid strains of Saccharomycopsis lipolytica, provided they carry a mutation affecting the first enzyme of the lysine pathway and confering resistance to end product inhibition. The phenotype can be stabilized in some sublines; it appears as dominant and coupled with a decrease in spore viability. Excretion in batch cultures is confined to the end of the exponential phase, and seems not to consist in a simple release of the lysine pool content. |
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